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Rett syndrome: Mirtazapine administered to the first patient

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After 15 years of research, including three dedicated to the collection of non-profit funding, the MirtaRett project coordinated by Enrico Tongiorgi (UniTS Department of Life Sciences), finally enters clinical practice with the administration of the first therapy to a young patient at the Gaslini Hospital in Genoa.

In February 2025, the Italian Pharmaceuticals Agency (AIFA) received the positive opinion of the National Ethics Committee for Paediatric Studies and thus gave the green light to the first worldwide trial on Mirtazapine in Rett Syndrome, a serious neurological disease that affects almost exclusively girls.

The clinical study, coordinated by the University of Trieste, will initially extend to 15 young patients and will take place in the main Italian reference hospitals for Rett Syndrome. The trial is fully covered by non-profit funds.

The project is supported by the unconditional contribution of Angelini Pharma SpA, Fondazione Canali Onlus, Fondazione Ico Falck and Fondazione Amadei and Setti. In addition to the pharmacological experimentation, the project also provides for the continuous monitoring of patients' vital parameters, such as breathing, heart rate and blood oxygenation. For this purpose, smart T-shirts are used, already distributed to hospitals in Genoa, Siena, Messina and Milan. Originally developed for monitoring athletes, these T-shirts are made of cotton woven with nanofibres capable of detecting the weak electrical signals of the human body and are tailor-made for each patient by the Italian company AccYouRate Group.

What is Mirtazapine?

Mirtazapine is a commercially available drug, therefore more easily accessible and sustainable. To facilitate its intake, a European company has been identified that can produce it in liquid formulation, a solution that is not widespread since the drug is normally marketed globally as tablets. ‘Our laboratory at UniTS Department of Life Sciences was the first in the world to demonstrate that mirtazapine, despite being an antidepressant, acts on broader mechanisms and can improve breathing, motor control, sleep quality and social communication in patients with Rett’s syndrome,’ explains Prof. Tongiorgi.

Access to the trial is open to new patients

In Friuli Venezia Giulia it is estimated that there are three or four girls affected by the syndrome who are not currently included in the study, but the prospects remain encouraging. ‘We hope that the health facilities in the region will also be able to participate in the trial,’ Tongiorgi said.

To ensure the scientific validity of the study, it is necessary to reach a total of 54 patients aged between 5 and 40 years, divided into the ranges 5-10, 11-17 and 18-40 years. Approximately one third have been recruited so the search for new participants is still open.

Abstract
At Gaslini in Genoa the MirtaRett project has now started: the first worldwide trial on a drug against this serious neurological pathology. The study is coordinated by Enrico Tongiorgi of UniTS
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Less noisy and more sustainable ships: DIA participates in the project ‘Acoustic Black Holes - SilentShip’

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Improve comfort on board, resetting the vibro-acoustic footprint to protect the marine environment and ensure the wellbeing of passengers and crew. These are the ambitious objectives that kicked off the research and development project ‘SilentShip - Acoustic Black Holes, a new frontier for silent ships’.

The initiative, strategic and co-financed by the Regional ERDF Programme of the Friuli Venezia Giulia Region, sees the Department of Engineering and Architecture (DIA) of the University of Trieste as a scientific partner, alongside industrial leaders such as Fincantieri and Esteco, with the management support of MareFVG. The project leader is Consorzio Servizi Navali e Industriali - CSNI.

The key to innovation lies in Acoustic Black Holes (ABH), devices based on a particular geometry and applied to parts of the structures. In practice, these geometries cause vibrations to ‘concentrate’ there: mechanical energy slows down and is more easily dissipated by dedicated materials or treatments. This is why ABHs are described as real ‘wells’ of vibrational energy. The use of this technology makes it possible to design light and sustainable solutions to limit the propagation of vibrations generated by the main machinery and, consequently, to contain the noise perceived on board and radiated outwards.

Within the project, the Department of Engineering and Architecture will play a crucial role ranging from theory to experimentation. The research team is led by Giada Kyaw Oo D'Amore, junior researcher at DIA, as scientific project manager and UniTS coordinator and includes Prof. Marco Biot, Prof. Mitja Morgut and Giovanni Rognoni, research assistant at DIA.

UniTS researchers will focus on developing advanced numerical models and performing complex simulations aimed at identifying the most effective ABH geometries and the essential parameters to optimise them. These analyses will also produce useful guidelines to establish where to place prototypes on naval structures to obtain the maximum effect.

The research group will also provide a fundamental contribution in the validation phase, in fact it will design and conduct progressive tests, from the laboratory to naval mock-ups, up to the tests on board the ship. These activities will be used to detect the real stresses that vibrations generate, so as to insert them accurately in numerical models. Tests will also be used to verify the effectiveness of the solutions identified on the computer and to refine the prototypes, ensuring that the expected performance in simulation is confirmed even under operational conditions.

Finally, the commitment of the DIA will extend to sustainability and open innovation aspects. The team will carry out Life Cycle Assessments (LCA) of the developed product and will conduct studies to apply Open Innovation solutions consistent with the philosophy of Company 5.0, in which technological progress is oriented both towards improving quality of life and reducing environmental impacts. The Department will also contribute to the definition of the technical specifications of the product and the production process.

The ‘SilentShip’ project has a total funding of € 1,366,685.17, with a regional contribution of € 822,016.20 and EU co-financing of € 328,806.48. The budget available to the UniTS team amounts to € 418 130.20, confirming the importance of the research work carried out by researchers at the University of Trieste.

With a duration of 42 months, the project aims to set a new technological frontier in the naval sector, making vessels not only more comfortable for humans, but also more respectful of the marine environment.

Abstract
The UniTS team is a partner of CSNI, Fincantieri and Esteco: develop numerical models and experimental tests to reduce vibration and noise on board, with attention to sustainability and open innovation
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iNest Innovation Ecosystem: the results of the spoke coordinated by UniTS presented to the public

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The objective of iNEST (Interconnected North-East) Innovation Ecosystem Spoke 8, coordinated by the University of Trieste was the development of maritime, marine and inland water technologies and the creation of a Digital Twin of the Northern Adriatic Sea. The results were presented during the final event of the project funded by the National Recovery and Resilience Plan (NRRP). The event was organised at the San Giusto Castle in Trieste by UniTS and its partners, including the National Institute of Oceanography and Applied Geophysics (OGS), the Eastern-Adriatic-Sea Port Authority (PNAEAS) and the Andrea Galvani High-Adriatic Technology Hub (PTAA). ‘The activities of Spoke 8,’ stressed prof. Pierluigi Barbieri, iNEST coordinator at the University of Trieste ‘are inspired by European priorities and the ambitious programme called “Starfish Mission” aimed at knowing, protecting and restoring our waters by 2030. The mission sets out five general objectives: closing the knowledge gap, renewing governance related to the management of marine and coastal environments, regenerating marine and freshwater ecosystems, reaching zero pollution, decarbonising water. The theme of water management and the Blue Economy is taking on increasing economic, political and social interest and touches on multiple sectors, including transport, logistics, security, fisheries, tourism and underwater activities. The NRRP-funded initiative for research-based innovation brings contributions in terms of data acquisition systems, integration of information for sustainable management of coastal areas, technologies for adaptation to climate change’.

The event called ‘Maritime, marine and inland water technologies: towards the Digital Twin of the Upper Adriatic’ was an opportunity to reflect on possible design developments. ‘Researchers from public bodies and innovators from companies in the North-Eastern and Southern Italy,’ explained prof. Pierluigi Barbieri ‘have developed data, models and products generated by specific activities and convergences between contiguous areas.’ Over €6 million funding was allocated to 24 research, development and innovation projects, with 53 beneficiaries, including 39 private bodies and 9 public research bodies from North-Eastern and Southern Italy. 34 small enterprises, 4 SMEs and 6 large enterprises were involved, supporting R&I and collaborative research in the thematic area of Spoke 8.’ The activities of Spoke 8 and those of the companies working with the University of Trieste have focused on applied research, not neglecting organisational, economic and legal aspects that regulate the transition to a more integrated and sustainable vision and management of the marine and aquatic environment in general. The digital transformation of companies operating in the Blue Economy sectors has been identified as a fundamental pillar of the smart specialisation strategy to support the competitiveness of SMEs operating in the iNEST ecosystem, favouring their conversion to new products and services with greater added value, increasing their degree of internationalisation.

The five general objectives 

Biology of marine ecosystems 

The digitalisation of marine life has begun, including life that is still unexplored, thanks to tools capable of mapping physical and genetic aspects: the databases obtained open up new perspectives for innovative sectors, from biotechnology to sustainable fisheries and tourism. A living sea is a productive resource capable of generating value, wealth and future.

Innovation in managing physical and chemical risks and their impact on the hydrosphere 

The Universities of Trieste, Trento and OGS are collaborating on a project that studies the chemical and acoustic risks of the sea, simulates extreme climatic events and analyses the effects of storm surges. Methods are also being developed to reduce the impact of wastewater and monitor pollutants, creating a digital twin to predict and manage environmental balance.

Innovation in sustainable maritime transport 

A new means of tourist transport along the Trieste coast is being developed. Thanks to hybrid-electric propulsion, it can also be used for daily travel. Strategic routes have also been redefined and research infrastructures designed for a sustainable mobility system.

Integrated land-sea maritime and space planning 

The research activity focuses on the coastal areas of North-Eastern Italy, in particular Friuli Venezia Giulia, characterised by the alternation of fresh and salt water, wetlands and dry areas. The project analyses these dynamics from an unexplored perspective: looking from sea to land, with an emphasis on sustainable and integrated mobility between sea, inland waters and land.

A digital twin of the Upper Adriatic 

It is a virtual representation of a physical system that allows you to explore scenarios and obtain answers applicable to reality. The aim is to create a Digital Twin of the Northern Adriatic by integrating observations and models. By providing for the physical and biogeochemical properties of the marine ecosystem, this instrument will support both human activities and environmental protection.

Abstract
The investment worth over €6 million involved 53 beneficiaries, including 39 private bodies and 9 public research bodies from North-Eastern and Southern Italy. 34 small enterprises, 4 SMEs and 6 large enterprises involved to support R&I and collaborative research
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UniTS researchers create a Generative Artificial Intelligence assistant for the clinical management of Hepatitis C

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Artificial intelligence capable of translating international guidelines for the treatment of hepatitis C into clear clinical responses consistent with the most up-to-date standards: this is the focus of an international study led by Mauro Giuffrè, PhD student at the University of Trieste (Department of Medicine, Surgery and Health Sciences) and researcher at the Yale University School of Medicine, validated by the same authors of the European guidelines for the treatment of the disease.

Hepatitis C is an infection caused by HCV, which affects the liver and can develop into chronic forms with serious complications, such as cirrhosis and hepatocellular carcinoma. According to the World Health Organisation, around 58 million people worldwide live with chronic infection and there are over 1.5 million new cases each year. WHO has set an ambitious goal of eliminating hepatitis C as a public health threat by 2030, aiming to reduce new infections by 90% and deaths by 65%.

The development of innovative tools based on artificial intelligence, such as that presented in the study by the University of Trieste, plays a key role in pursuing these objectives: Improving adherence to therapeutic guidelines and facilitating access to appropriate care even in contexts with limited resources are concrete steps that can contribute to achieving global targets.

Significant improvements in clinical accuracy

The team developed and tested two innovative approaches to specialise GPT-4 in HCV management. On the one hand, they developed a retrieval-augmented generation (RAG) system that integrates European guidelines in real time which has been tested in two variants (RAG-Top1, which retrieves the single most relevant paragraph, and RAG-Top10, which retrieves the ten most relevant paragraphs). On the other hand, they developed a supervised fine-tuning (SFT) training of the language model on the guidelines’ contents.

The results exceeded all expectations: compared to 36.6% of the GPT-4 base model, the RAG-Top10 model achieved an accuracy of 91.7% in expert evaluations, RAG-Top1 81.7% and the SFT model 71.7%, thus achieving significant improvements compared to the standard model.

A novel validation system that includes guideline extenders and clinical experts

What makes this study particularly relevant is the applied validation methodology, a new entry in the scientific literature. Two separate groups of evaluators were recruited. The first group consisted of four expert hepatologists, selected from the lead authors and chairs of the HCV guidelines of the European Association for the Study of the Liver (EASL), the leading European experts in the treatment of hepatitis C and the drafters of the international guidelines.

A second group of hepatologists was added from a tertiary reference centre (Humanitas Hospital, Rozzano), ensuring a double perspective of evaluation between guideline theorists and clinical

practitioners in the field. This approach allowed us to obtain what the researchers themselves define as ‘an evaluation that approaches the gold standard in defining the accuracy of the outputs.’

Towards responsible integration of AI in medicine

The findings open up concrete perspectives for the use of artificial intelligence in clinical decision support. Both RAG and SFT significantly improve the performance of Large Language Models (LLMs) in managing hepatitis C through guidelines, improving not only the accuracy and clarity of responses, but also the selection of therapeutic regimens in clinical scenarios. The study represents a significant step towards what the authors call ‘the safe integration of Generative Artificial Intelligence into clinical practice’, confirming the potential of specialised and expertly validated language models as concrete decision support tools in medicine, particularly valuable in highly complex contexts such as the management of chronic liver diseases. The research, presented in the article From Guidelines to Real-Time Conversation: Expert-Validated Retrieval-Augmented and Fine-Tuned GPT-4 for Hepatitis C Management, published on Liver International, was supported by Nicola Pugliese and Alessio Aghemo (Humanitas University), bioengineers from the University of Trieste Simone Kresevic and Milos Ajcevic (Department of Engineering and Architecture) and an international network of hepatologists and artificial intelligence specialists, including Dennis L. Shung (Yale), Francesco Negro (University Hospitals of Geneva), Massimo Puoti (Niguarda General Hospital; University of Milan Bicocca), Xavier Forns (Hospital Clínic Barcelona; IDIBAPS; CIBERehd) and Jean-Michel Pawlotsky (UPEC/INSERM; AP-HP Paul Brousse, Paris).

Abstract
The study coordinated by Mauro Giuffrè (DSM) saw the participation of the authors of the European guidelines for the treatment of the disease. Among the main authors, also Simone Kresevic and Milos Ajcevic (DIA UniTS), Nicola Pugliese and Alessio Aghemo (Humanitas University)
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Allergy to Nickel: a UniTS – ASUGI published study

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A study conducted by UniTS professors Luca Cegolon (also working at ASUGI Hygiene and Preventive Medicine Department) and Francesca Larese Filon (ASUGI Occupational Medicine Department) has just published in the international scientific journal Contact Dermatitis (Wiley). The researched was focused on contact allergy to 5% nickel sulfate in 31,948 patients who underwent patch tests in Triveneto from 1997 to 2023.

Nickel is the most frequent cause of contact allergy, a hypersensitivity that can develop after repeated and prolonged skin exposures to allergens.

In 1994, EU Directive 94/27/EC restricted the use of nickel in jewellery and other consumer products that may come into contact with human skin.

Although this measure has led to a progressive reduction in nickel awareness in Europe, the benefit has mainly been seen in younger generations. Older people, on the other hand, who were sensitised before the entry into force of the Directive, contribute to the prevalence of nickel contact allergy at the global level.

In detail, the geographical distribution of nickel awareness is heterogeneous and tends to be higher in Mediterranean countries than in Northern Europe, probably due to a late and less stringent application of the European Directive.

Outside the European Union, specifically in North America and Japan, there continues to be a higher and increasing prevalence of nickel sensitisation over the years, due to the lack of restrictive legislation in this area.

The University of Trieste study points out that the prevalence of nickel sensitisation was 26.1% during the study period (1997-2023), followed a progressively decreasing time trend and was significantly lower in males. The trend also revealed an inverted U-shaped trend with respect to the year of birth among women, falling from 35.70% in those born between 1955 and 1964 to 46.24% in those born between 1965 and 1974, to 41.36% among those born in 1975-1984.

The inverted U-shaped pattern of positive reactions to patch tests by year of birth reflects nickel exposure and sensitisation in women aged 20 to 50 years, prior to the entry into force of the European Directive.

As regards the work performed by the persons surveyed, there was a significantly higher prevalence of positive reactions to the patch test among traders, while it was lower among pensioners and housewives. A higher prevalence of positive reactions among traders could reflect prolonged exposure in professions involving coin manipulation, while age-related immunosenescence could explain the lower prevalence of sensitisation in pensioners and housewives.

Although decreasing over the years, the prevalence of positive reactions to nickel has nevertheless remained higher than that of the northern European countries, probably due to a late and less rigorous application of the aforementioned European Directive. Other factors that may contribute to the higher prevalence of sensitisation in Mediterranean countries than in Northern Europe include social trends that have prompted Italian women to use nickel-containing jewellery products early, and higher ambient temperatures that facilitate the release and penetration of allergens into human skin from nickel-containing products.

Abstract
Luca Cegolon and Francesca Larese Filon conducted a study involving about 32,000 Triveneto patients between 1997 and 2023
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Looking inside a quantum vortex

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An international study published in Nature Communications, coordinated by the National Optics Institute of the National Research Council (CNR INO) in Florence, studied the dynamics of vortices in highly interacting superfluids, identifying their fundamental mechanisms.

The study was carried out by the research group of Giacomo Roati at CNR INO, Francesco Scazza, associate professor of Physics of the Matter at UniTS, and the universities of Florence, Bologna, Warsaw University of Technology and the University of Augusta (Germany). 

 The investigated ‘vortexes’ are small reels of fluid that revolve around an axis, inside a lithium atom gas cooled to extremely low temperatures, just 10 billionths of a degree above absolute zero. Under these conditions, matter enters a state called superfluid, in which the viscosity disappears and the fluid flows without friction. The superfluid behavior of ultracold atoms is analogous to that of superconductors, where electric current can circulate without resistance, allowing the transport of current without loss of energy. In both systems, vortex dynamics play a key role as they can open a channel for energy dissipation.

Giacomo Roati, CNR-INO Research Manager at LENS and Head of the Research Group, explains: ‘The use of ultra-cold atomic gases has allowed us to study this phenomenon in a very controlled way, within real “quantum simulations”. The dynamics of the vortexes in the case studied share similarities with that in high-temperature superconductors, a field still under study. Understanding their motion is essential to assess dissipative effects and to design new high-efficiency superconducting systems, in which these effects can be minimised in a targeted manner, paving the way for cutting-edge quantum technologies.’

Abstract
UniTS involved in a study published in Nature Communications coordinated by the CNR National Optics Institute that opens new possibilities for the development of high-efficiency superconductors
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An articulated digestive system discovered in a jellyfish, similar to more complex organisms

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An international team of researchers, led by the University of Trieste and the National Institute of Oceanography and Applied Geophysics (OGS), has discovered in the jellyfish Cotylorhiza tuberculata (commonly known as ‘fried egg jellyfish’ or under the improper name ‘Mediterranean Jelly’) an articulated digestive system, similar to that of more sophisticated organisms, revealing a surprisingly complex internal anatomy that revolutionises the idea of jellyfish as ‘simple’ animals.

The results of the study were published in the scientific journal PLOS One.

Partners of the study include Elettra-Sincrotrone Trieste S.C.p.A., the University of Milan, the Slovenian National Building and Civil Engineering Institute of Ljubljana, the University of Primorska and the Aquarium in Piran.

Massimo Avian, associate professor at the Department of Life Sciences of the University of Trieste and Gregorio Motta, post-doc, commented: ‘In order to analyse the anatomical structure of the jellyfish, overcoming the difficulties linked to the fragility and opacity of the tissues, we used a state-of-the-art technique, injecting a resin into the gastrovascular system of the invertebrate which, once hardened, made it possible to obtain a perfect, three-dimensional copy of all the internal channels. The resulting cast was then analysed with an X-ray microtomography”.

The technique used by the researchers made it possible to discover real channels that branch off into the oral arms of the jellyfish, each of which has a central bottleneck, which functionally divides it into two semi-channels. Functional anatomy experiments, carried out by injecting non-toxic dyes into the stomach of live jellyfish to observe internal flows, have also shown that in these channels there is a two-way circulation. The seawater, rich in prey, is initially ingested by the innermost openings of the arms. After reaching the stomach cavity through the innermost semi-channel, after digestion, it descends to the second semi-channel (external), and then is expelled from the most peripheral and distal openings of the oral arms, expansions similar to large tentacles that are observed under the umbrella.

Valentina Tirelli, a researcher at the National Institute of Oceanography and Applied Geophysics (OGS) among the authors of the study, states: ‘It has always been thought that in jellyfish the same opening served as both mouth and anus. On the other hand, this study shows that there is also a specialisation in Cotylorhiza tuberculata, with pores dedicated to the entry of food and others to the expulsion of waste products, to form a system that resembles a “through-gut” digestive tract, typical of more evolved animals. A similar system had already been identified by some of the co-authors of this work in another jellyfish, Rhizostoma pulmo. As these two species are phylogenetically distant, we hypothesize that this complex digestive mechanism could be much more prevalent among jellyfish than one might imagine.’

The research allowed to deepen the study of the biology of a common creature in our seas, demonstrating through modern observational techniques that evolution can produce complex solutions independently and unexpectedly, even in organisms often considered erroneously primitive.

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Full study published on PLOS One

New advances in jellyfish anatomy: the benefits of endocasts and X-ray microtomography in the investigation of the gastrovascular system of Cotylorhiza tuberculata (Scyphozoa; Rhizostomeae; Cepheidae)

Gregorio Motta1,2*, Marco Voltolini3, Lucia Mancini4, Diego Dreossi5, Francesco Brun6, Valentina Tirelli7,8, Lorenzo Peter Castelletto1, Manja Rogelja9, Antonio Terlizzi1,8, Massimo Avian1

  1. Department of Life Sciences, University of Trieste, Trieste, Italy
  2. Department of Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, Napoli, Italy
  3. Department of Earth Science Ardito Desio, University of Milano, Milano, Italy
  4. Slovenian National Building and Civil Engineering Institute, Ljubljana, Slovenia
  5. Elettra-Sincrotrone Trieste S.C.p.A., Basovizza, Trieste, Italy
  6. Department of Engineering and Architecture, University of Trieste, Trieste, Italy
  7. National Institute of Oceanography and Applied Geophysics, Trieste, Italy
  8. National Biodiversity Future Center (NBFC), National Biodiversity Future Center, Palermo, Italy
  9. University of Primorska, Aquarium Piran, Piran, Slovenia

 

Abstract
The study by UniTS (Massimo Avian and Gregorio Motta) and OGS, which made the discovery regarding the Cotylorhiza tuberculata jellyfish, is published in PLOS ONE
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Nuclear Magnetic Resonance Imaging: inauguration of a new laboratory at UniTS

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The Department of Chemical and Pharmaceutical Sciences (DSCF) has inaugurated its new Nuclear Magnetic Resonance (NMR) laboratory, the only one in the region with equipment this powerful. 

The laboratory is equipped with two latest generation spectrometers of 600 MHz and 400 MHz for a total value of more than one million euros. 

Nuclear Magnetic Resonance (NMR) spectroscopy, known above all for diagnostic applications in medicine, originates in the chemical field where it represents an extremely powerful investigative tool: it allows you to determine the structure of molecules in solution, from the simplest to the largest and most complex such as proteins.

For this reason, NMR is a key technique in the development of numerous lines of research in chemistry and biology.

At UniTS, NMR is used both for the basic molecular characterisation of different systems, ranging from catalysts for the production of innovative polymers to drugs and biologically active molecules, and for advanced studies of functionality and interactions in complex systems and nanosystems. In recent years, research has increasingly focused on sustainable chemistry and the development of alternative energies and materials, where NMR plays a crucial role.

The NMR Laboratory is also a strategic teaching resource and is used for theoretical and practical activities in the degree courses in Chemistry, Pharmacy, and Pharmaceutical Chemistry and Technology, contributing to the education of highly qualified graduates.

The investment is part of the programme to upgrade scientific instruments launched in 2022 with an extraordinary call for tenders for the purchase of state-of-the-art equipment, which has already enabled the acquisition of equipment for over 4 million euros.

Abstract
Two latest generation spectrometers of 600 and 400MHz will give a new boost to research and teaching
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UniTS launches the challenge for barrier-free tourism

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In the week celebrating International Day of Persons with Disabilities (3rd December), UniTS announces the results of the ‘Inclusive Tourism for Everyone’ Hackathon, promoted as part of the European Shaping Inclusive Tourist Experiences (SITE) project funded by the Interreg Italy-Croatia Programme 2021-2027.

The SITE project is coordinated by Lorenzo Castelli, associate professor of Operational Research at the Department of Engineering and Architecture (DIA) of the University of Trieste, in collaboration with the Trieste Inclusion and Accessibility Lab (TrIAL) research group, led by Ilaria Garofolo, full professor of Technical Architecture at the same department.

The aim of SITE is to increase the attractiveness of destinations in the programme area throughout the year by spreading a cross-border culture of Universal Design in the tourism ecosystem, thereby reducing the architectural, sensory and communication barriers that limit access for people with disabilities and other groups with specific needs, such as families and the elderly.

The Hackathon, moderated by Caterina Vidulli, founder of Central Marketing Intelligence and communication manager of the SITE project, was organised by UniTS Trieste together with the Italian and Croatian partners of the project, with the participation of the Municipality of Trieste, Promoturismo FVG, CRIBA FVG, INU (Italian Institute of Urban Planning) and the Start-Up Turismo association. 

Thirty-four university students from Italy, Croatia and Slovenia were involved, studying a variety of subjects: architecture, urban planning, languages, tourism management, social sciences and computer science. Among the mentors who supported and guided the work were experts in environmental accessibility, easy language, tourism marketing, sociologists and representatives of Cooperativa Oltre Quella Sedia.

Over the course of two days, participants were asked to develop innovative ideas and solutions that integrate the principles of universal design, with the aim of designing tourist experiences that are truly welcoming, accessible and enjoyable for everyone: people with disabilities, families, the elderly and visitors with limited language skills. The multidisciplinary groups collaborated in an atmosphere of strong creativity and problem-solving, bringing together technical, design and social skills.

A particularly significant moment was the guided tour of the city, conducted by PromoTurismo FVG with the participation of CRIBA FVG and the Cooperativa Oltre Quella Sedia. The experience allowed the teams to observe the urban context of Trieste first-hand and identify some of the main critical issues experienced by tourists when travelling around the city. 'The tour offered participants a concrete look at the difficulties that many visitors encounter on a daily basis. This is where truly attentive and inclusive tourism can begin,' says Paola Pascoli, representative of CRIBA FVG.

The winning projects

1st place – 'PathMate'

The PathMate project proposes an app that accompanies the user, adapting to their needs and enhancing their autonomy. PathMate simplifies travel planning, offers clear, multi-channel navigation and provides useful information on path characteristics and access, such as gradient and surface type. Team: Iftekhar Anwar (Computer Science, Polytechnic University of Turin), Arsenii Prostakov (Languages, ‘Federico II’ University of Naples), Anastasija Ristova (Urban Planning, University of Ljubljana), Lucija Oštarić (Tourism Management, Rijeka), Alessia Gaia Russo (Communication Design, Polytechnic University of Milan).

2nd place – ‘APO – All Paths Open’. 

A participatory system that connects tourists with disabilities or specific needs to residents who share the same condition, with the aim of building a safe, informed, sensitive and involved community. Team: Patricia Ivančić (Social Sciences, University of Rijeka), Eleonora Lazarova (Urban Planning, University of Ljubljana), Jana Krivošić (Tourism Management, Rijeka), Alessandra Airaudo (Digital Marketing, Unicusano).

3rd place – 'TourAble'

An app designed to make tourism truly accessible thanks to its inclusive, intuitive and adaptive design. TourAble encourages citizens' awareness of accessibility issues and offers barrier-free routes, activities for families and information dedicated to people with visual and cognitive disabilities. Team: Daniyar Yegeubay (Computer Science, ‘Federico II’ University of Naples), Ester Calenda Casarin (Languages, ‘Ca' Foscari’ University of Venice), Pia Ržen (Architecture, University of Ljubljana), Korina Zorić (Tourism Management, Rijeka), Marianna Capriotti (Tourism Management, University of Perugia).

‘Participating in the Inclusive Tourism for Everyone Hackathon of the SITE – Interreg ITA CRO 2021-27 project was a valuable experience, both professionally and personally. Seeing so many young people from the world of tourism working with competence, curiosity and a sense of responsibility towards a more accessible future was deeply motivating,’ said Annalisa Novacco of Willeasy, one of the members of the jury. ‘At Willeasy, we enthusiastically accepted the invitation from the Startup Turismo association, whom I sincerely thank for highlighting the role of accessibility within the programme. On this occasion, I had the honour of representing Willeasy, as a member and delegate for accessible tourism issues, helping to bring the voice of those who work every day for a more inclusive sector. Presenting the awards to the winning teams was a symbolic but significant gesture: the dialogue between those who are working today to make the world more inclusive and those who will be able to transform this vision into new standards tomorrow is the real strength of an evolving sector. The commitment and sensitivity shown by the participants confirm that innovation and attention to people are not parallel tracks, but the same direction. This is the energy needed to build a tourism industry that is capable of welcoming, understanding and truly including everyone.

The jury also included professors Ilaria Garofolo (DIA, University of Trieste) and Jelena Durkin Badurina (FTHM, University of Rijeka); Roberta Gigli, representative of the Forum of Adriatic and Ionian Cities; and Erika Kosic, representative of the Friuli Venezia Giulia Region in its quality of joint secretariat of the Italy-Slovenia programme.

The other projects

The other projects presented offered diverse solutions but were united by a single inclusive vision: from the creation of universally accessible, comfortable, free, temporary modules equipped with information screens (the ‘Your Pod Stop’ project) to the development of a certification protocol for diversity-conscious services (the ‘Inclusive Tourism’ project). An app designed to connect tourists and residents with similar needs (the ‘Help’ project) and an inclusive travel platform that generates personalised maps using content verified by artificial intelligence and real data from social media (the ‘AllWays’ project) were also presented.

In addition to cash prizes for the three best projects (€ 4,000 for first place, € 2,000 for second place and € 1,000 for third place), funded by the Start-Up Turismo association, the winners will have access to mentoring sessions with the association and SITE project partners, and will be invited to the project's final international conference, to be held in Opatija (Croatia).

The Hackathon ended with a shared understanding that designing more inclusive tourism means contributing to the development of more open, welcoming and sustainable communities.

Abstract
As part of the European SITE project – Shaping Inclusive Tourist Experiences, awards given to the best ideas for more accessible tourism
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Naval electrical applications: the V-access-project superconductor and supercapacitor tests were concluded in Trieste

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The two-day ELECTRIC SHIP SUPER STORAGE EVENT that was part of the V-ACCESS project concluded in Trieste on 3rd December. The event focused on shipboard electrification through the use of innovative technologies, such as superconductors and supercapacitors for energy storage and was attended by all the companies and university research units involved in the project.

The V-ACCESS project, coordinated by the University of Trieste, is dedicated to the development of a new generation of hybrid energy storage system (HESS), combining superconducting magnetic energy storage (SMES) technology based on magnesium diboride (MgB2) with supercapacitors.

Combining these two technologies to support batteries constitutes a major innovation in terms of both performance and reliability across energy storage and the release of strong energy impulses.

The strength of this technology lies in its uniqueness, and the solution proposed by the project will be applied not only in shipping and ship electrification but also in energy-intensive industrial sectors. In addition, innovation in storage systems will play a key role in power systems and will also be essential to balance energy production and consumption in electricity grids in response to the increasing integration of renewable sources and the needs of the green deal.

The V-Access project has been financed with European funds for a value of € 5,000,000 and is optimised to integrate with battery systems on board vessels. The advantage of the solution designed as part of the project lies in the hybrid management of a superconducting SMES accumulator and supercapacitors. The SMES accumulator is made of MgB2 and was designed and built by ASG Superconductors, while the supercapacitors were designed and built by Skeleton as part of a project that also involves Fincantieri, VARD, RINA, RSE, SINTEF, the universities of Trieste, Genoa and Birmingham and Politecnico di Milano.

SMES superconductor technology is ideal for short-term, high-power energy storage, perfect for power modulation and instantaneous voltage stabilisation. Supercapacitors, on the other hand, are electrostatic storage devices that offer very fast power delivery and absorption (high power density) and have an extremely long service life (millions of cycles). The hybrid interaction of these technologies with traditional batteries, in addition to extending their use cycle, allows for innovative load management and therefore the reduction of CO2 emissions.

Tests on the SMES superconducting system created by ASG Superconductors and the Skeleton supercapacitors were carried out at the Electric TEst Facility (ETEF), the testing laboratory for applications of electrical energy systems in marine environments, born from the partnership between the University of Trieste, Wärtsilä and Fincantieri as part of the Italian General Secretariat of Defence’s national scientific and technological research programmes.

Giorgio Sulligoi, a full professor at UniTS, stated that ‘ETEF is the flagship project at Trieste’s experimental facilities, a hub where academic and industrial researchers work together to define the future of electric vessels.’ He went on to conclude that ‘the synergy between companies and the academic world behind the V-Access project has already made tangible steps towards hybrid electrification technology that will be useful and necessary not only in the shipping sector but in all applications that require large and rapid energy pulses.’

Pietro Tricoli of the University of Birmingham and technological coordinator of the project, added ‘the supercapacitor and superconducting SMES prototype has been tested in a highly realistic operational environment, aiming for a technological readiness level (TRL) of 5, a step ahead of future developments linked to projects for the development and installation of this technology on board the ship. ‘

Gianluca Bertossi, Managing Director of Wärtsilä Italia said: ‘The ETEF prototype is an important research and technological de-risking infrastructure for the on-board electrical systems of future vessels. It makes the pursuit of similar objectives equally possible for land-based applications that share similar requirements for power quality, quality of service and reliability. There is no system in Europe with comparable performance in terms of installed power, technological characteristics, performance and testing capabilities.’

Marco Nassi, CEO of ASG concluded: ‘the V-ACCESS project presented all of us with a challenge and we thank all the partners for the work that has led to the successful testing of our SMES at the invaluable ETEF. We believe that superconducting storage is a high-tech solution that is ideal for meeting the innovation and resilience needs of networks.’

Abstract
The international project is coordinated by UniTS
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