A study carried out by the University of Trieste in collaboration with Yale University, published by Nature Npj Digital Medicine, has entered the top ten of the most cited articles in 2024 in the prestigious scientific journal, coming eighth in the ranking drawn up by the publisher.

The article entitled ‘Optimization of hepatological clinical guidelines interpretation by large language models: a retrieval augmented generation-based framework’ saw the contribution of an interdisciplinary UniTS research team, consisting of Simone Kresevic, PhD student in Biomedical and Clinical Engineering, Miloš Ajčević and Agostino Accardo from the Department of Engineering and Architecture, and Lory Saveria Crocè, gastroenterologist from the Department of Medical, Surgical and Health Sciences.

The study benefited from the collaboration between the group of researchers from the University of Trieste and the Yale School of Medicine, in particular the Human+Artificial Intelligence in Medicine centre in New Heaven (Connecticut, USA), with contributions from Dennis L. Shung, director of the research laboratory, and Mauro Giuffrè, co-authors of the paper.

The researchers explored the use of generative AI systems capable of understanding and generating human language by processing large amounts of data, Large Language Models (LLM), to optimise clinical decision support in the field of medicine.

In this study, a digital infrastructure (framework) based on LLM was therefore developed which, through the correct formatting of clinical guidelines, could improve their consultation and application in clinical practice.

The research focuses, in particular, on the integration of these Artificial Intelligence models to improve the interpretation of medical guidelines relating to the management of chronic infections caused by the hepatitis C virus (HCV).

This system, using Retrieval Augmented Generation (RAG) techniques, a method of extracting relevant information from clinical guidelines, reprocessing it using LLM and, through the generative process, providing answers to guideline-related questions in a clear and accurately structured manner.

The research activity now continues to expand the functioning of the framework on different liver diseases. This strand of research could offer a system capable of supporting physicians with decisions based on the best available scientific evidence.

‘With this approach,’ explains Dr Simone Kresevic, first author of the article together with Mauro Giuffrè, ‘we are laying the foundation for using artificial intelligence in everyday clinical practice. Evidence-based medicine, a fundamental pillar of modern medicine, aims to integrate the best available scientific evidence with clinical experience and patients' needs. However, the complexity and volume of clinical guidelines often represent a significant barrier in their application.'

'Through this framework,' Kresevic concludes, ‘we can offer a tool to support the clinician and thus support evidence-based and personalised medicine, bridging the gap between high-quality research and practical healthcare, especially in complex areas such as hepatology.’

On the night of 27th January, UniTS will light up its façade in red as a poignant reminder that International Holocaust Remembrance Day, dedicated to honouring the victims of the Holocaust, is commemorated worldwide.

The date was established by the United Nations General Assembly because on 27th January 1945 Soviet Red Army troops, engaged in Operation Vistula-Oder towards Germany, liberated the Auschwitz concentration camp, revealing the horrors of the Nazi regime to the international community.

In order to deepen the knowledge of the Shoah and deportations, on Monday 27th January 2025, starting at 16:00, at the Miela Theatre, there will be the 11th edition of the multidisciplinary conference ‘Living with Auschwitz. The atrocity’. 

PROGRAMME: https://portale.units.it/en/events/multidisciplinary-conference-living-auschwitz-atrocity

The initiative, born from the collaboration between the University of Trieste and the cultural association Stazione Ernesto Nathan Rogers, is part of the Rogers' Forum event, financed by the Friuli Venezia Giulia Region.

The complete calendar of commemorations in Trieste can be consulted here: https://www.comune.trieste.it/it/novita-227102/comunicati-227104/27-gennaio-2025-giorno-della-memoria-cerimonia-commemorativa-alla-risiera-di-san-sabba-e-programma-attvita-culturali-291581

Moreover, from 26th February to 3rd March 2025, about forty students will take part in a trip to the former Auschwitz-Birkenau concentration camp, part of the project ‘Promemoria_Auschwitz’ promoted by the association Deina APS. Information can be found here: https://www.deina.it/promemoria-auschwitz

A hall crowded with UniTS students ready to leave for the Erasmus+ Study Programme, dedicated to bachelor's, master's and PhD students.

The UniTS International Day has proved to be a not-to-be-missed event for students who want to experience training abroad: the stories of those who have already lived this kind of experience and the information provided by the university staff demonstrated all the advantages of the Programme.

As special guest, there was the science journalist and biologist Cristina Serra.

The numbers of UniTS Erasmus+ Study are excellent: the funding obtained is about € 1,600,000 while the evaluation received by the National Agency of the Programme for the management of activities is the highest in the last seven years (a score of 90/100).

The numbers of outgoing students are on the rise with 522 assignments for 2024/25 (+9.4 %), while those expected to arrive (incoming) are slightly up with 206, a number that is destined to rise.

Also noteworthy is the growth in the Short-Term Mission reserved for doctoral students with 32 assignments in 2023/24 (compared to 15 in the previous round), the participation of lecturers (+ 90%) and university staff (+ 74%).

The Urology Department of the Cattinara Hospital, a university facility that is the seat of the UniTS Specialisation School in Urology, demonstrates national excellence in the treatment of prostate cancer.

The Prostate Cancer Unit of Trieste, in fact, has obtained for the second consecutive time the Bollino Azzurro (blue stamp) awarded by Fondazione Onda ETS, the national observatory on women's and gender health. The award is intended to identify virtuous centres offering prevention, diagnosis, treatment and rehabilitation services in the uro-andrological field from a multidisciplinary perspective, with a focus on prostate cancer and functional post-surgical complications.

Prof. Giovanni Liguori, Head of the Urology Department of ASUGI (local health services) and Professor of Urology and Andrology at the University of Trieste, says: ‘The awarding of the Bollino Azzurro recognises our commitment to making available to patients, suffering from both cancer and benign pathologies, not only innovative therapies, but a global approach that considers the multiple aspects of uro-andrological health, integrating prevention and treatment and paying great attention to preserving the quality of life.’

‘An approach,’ continues Prof. Liguori, ‘that both Prof. Paolo Umari and I aim to transfer to the new generations of urologists that we train in the UniTS specialisation school.’

The Prostate Cancer Unit in Trieste, coordinated by Dr. Gianluca D'Aloia, is made up of specialists from different branches, including urologists, oncologists, radiologists, radiotherapists, anatomic pathologists, nuclear medicine specialists, and nurses, who guarantee comprehensive care and customised therapeutic solutions.

‘In parallel with Bollino Rosa (pink stamp),’ explains Dr. Luisa Dudine, Fondazione Onda's territorial representative, ‘which is dedicated to the commitment to care and assistance for the health problems that most affect women and require specific approaches and skills, Bollino Azzurro focuses on the diseases that most affect men. Cancer units must be able to address not only the health problems of patients, but also the effects on those close to them.’

The University of Trieste has been fitted out with a new ‘Simulated Pharmacy’ laboratory, which will be available to students from the integrated master’s degrees in Pharmacy and Pharmaceutical Chemistry and Technology.

This type of laboratory, which can be found in only three other universities in Italy, will enable students to carry out exercises extremely useful for their entry into the world of work. This is in line with growth in the pharmacist profession in recent years and new healthcare services provided by local pharmacies. The aim is to supplement the theoretical courses in the 4th and 5th years of Pharmacy and PCT programmes with practical experience in the field.

The Laboratory is a physical space, equipped like a real pharmacy open to the public, where learning focuses on experiencing the ‘pharmacy’ environment, aspects of pharmaceutical technology, socio-economics, pharmaceutical legislation and self-medication management. 

In the ‘Prescription Area’ there is a counter with two workstations equipped with management software. In the ‘Health and Wellbeing Area’ there is another counter and displays of health products. In the ‘Service Booth’, students will instead find equipment for ECG analysis, spirometers, pulse oximeters, sphygmomanometers, a vaccine injection simulator and much more. The area is also equipped with a refrigerator and a section for preparing medicines. There is also a classroom area equipped with a projection system.

The creation of the Simulated Pharmacy was made possible thanks to the collaboration of Telaro, Aboca and the Consorzio Farmacisti Riuniti.

The objective of KNIGHT (Knowledge base for Nile Geo-Hazards Tackling) is to strengthen resilience to geo-hazards and climate challenges along the Nile corridor, increasing the capacity to manage emergencies. It is a project promoted by the National Institute of Oceanography and Applied Geophysics (OGS) that sees participation from the Department of Engineering and Architecture (DIA) at the University of Trieste.

The project, co-financed by the Friuli Venezia Giulia Region, was officially launched on 20th January. It will last two years and counts among its partners the Municipality of Lignano Sabbiadoro, Cooperative Shoreline, the Faculty of Science at the Damietta University (Egypt) and the National Research Institute of Astronomy and Geophysics (NRIAG, Egypt).

KNIGHT is aimed at natural disaster mitigation and emergency management. More specifically, it aims to strengthen the resilience of the natural, economic and cultural heritage along the Nile River and its delta. It does so by supporting the review of the national plan for natural hazard mitigation with data, models and innovative technologies.

Within this highly multi-disciplinary project, a research team from the University of Trieste composed of Chiara Bedon (DIA), Marco Fasan (DIA) and Fabio Romanelli (MIGe) will focus on advanced structural and seismological analysis, also using innovative methods and technologies. Their goal is to characterise and assess the seismic risk and vulnerability of some case-study buildings that will be identified along the course of the Nile. All this will contribute to drawing up natural risk exposure maps, the identification of optimal strategies for the prevention of natural disasters, and the establishment of emergency management procedures.

The collaboration between the partners will allow for the sharing of data that will be analysed, standardised and integrated into a database using a GIS platform, making it possible to identify the areas most subject to anthropic and/or natural stress (and therefore most vulnerable), and to assess natural hazards and possible cascading risks in order to mitigate them.

‘There are three main activities that will be carried out. First of all, work will be done to develop a data and knowledge base for the integrated assessment of geological and environmental risks at selected sites along the Nile, the delta and the surrounding coastal areas. At the same time, new methodologies for integrating multi-hazard scenarios and environmental monitoring will be tested at key sites along the course of the Nile, ranging from the Aswan Dam to the coastal areas of the delta, with a special focus on the area of Damietta, a city of significant economic and social interest. Finally, specialised training, technology transfer, citizen-science and awareness-raising activities will also be carried out,' says Antonella Peresan, seismologist at OGS and coordinator of the project.

‘These activities,’ concludes Peresan, ’will over the 24 months of the project lead to concrete and useful products for the future: the creation of an archive of data and knowledge and the development of shared guidelines to improve the resilience of the natural and environmental heritage in the area of intervention, an area where natural events and climate change can significantly affect socio-economic growth.’

The activities of the Teaching and Learning Centre (TLC) of the University of Trieste have officially begun, with the first joint meeting of the Governing Board and the Scientific Committee, which took place in the presence of the Rector Roberto Di Lenarda and the Director General Luciana Rozzini.

The Centre was established under the leadership of Matteo Cornacchia, Professor of General and Social Pedagogy, to promote the continuous training of university lecturers with a view to innovation and improvement in teaching, with the aim of improving the effectiveness of teaching in relation to the changing student population and the digital tools available.

The TLC will be a useful tool to strengthen the idea of the ‘university teacher’ that UniTS intends to promote.

‘The launch of the Teaching and Learning Centre,’ explains Matteo Cornacchia, ‘is one of the actions envisaged in the University's Strategic Plan 2023-2026. TLCs have long been present in foreign universities and, for some years now, they have also been becoming more widespread in Italy with the aim of accompanying and supporting the improvement of university teaching and the professional development of lecturers and researchers.’

Among the first initiatives is the introduction of a compulsory course for newly recruited lecturers to facilitate their induction and foster their professional growth. It will also provide support for the design and delivery of innovative training courses.

‘Their task,’ says Cornacchia, ’is to foster Faculty Development, i.e. the set of activities needed by university lecturers to improve their knowledge, teaching and assessment methodologies, relationships with students, and to be more effective overall in their work.'

The TLC Governing Board comprises all the components of the academic community: in its first formation, it includes lecturers Silvia Palmisano (DSM), Pierre Thibault (DF), Dolores Ferrara (IUSLIT), Stefano Fornasaro (DSCF) and Giovanni Grandi (DISPES), the administrative manager (identified by the Director General) Enrico Sartor, Samantha Tedesco representing the technical and administrative staff and Enrico Candotti as the student representative.

The Scientific Committee, on the other hand, is composed of Sara Cervai (DISPES), Gianfranco Sanson (DSM), Francesco Venier (DEAMS), Danilo Lewanski (MIGE), Valentina Beorchia (MIGE - as Interdepartmental Centre for Research on Educational - CIRD), Emanuele Carosati (DSCF), Maria Chiara Passolunghi (DSV), Giovanni Bacaro (DSV), Paolo Labinaz (DISU), Eric Medvet (DIA), Lorenzo Di Pietro (DF) and Stefano Ondelli (IUSLIT), ensuring the representation of all the University's departments.

During the inaugural meeting, the members of the Centre's two bodies engaged in an initial discussion of the tasks of the TLC, also in relation to similar bodies in Italy and abroad, and began planning future activities.

The University of Trieste presented at the Urban Center the five winning projects of ‘Call4Ideas’, which, in addition to allocating 75,000 euros in funding, aims to build a bridge between university research and the world of production in order to increase the technological readiness of local businesses.

‘Call4Ideas’, promoted by the University of Trieste in cooperation with the Polo Tecnologico dell'Alto Adriatico, is an initiative financed by the National Recovery and Resilience Plan (NNRP) through NextGenerationEU that is being implemented as part of the North-Eastern Innovation Ecosystem iNEST - Spoke 8 (coordinated by UniTS), specifically in the cross-sector activity CC2 ‘Lab Villages’.

In the first phase, the call for proposals saw local companies propose research trajectories, identified as priorities for the development of their activities consistent with the strategic areas of iNEST: blue economy, life sciences, digital, sustainability and material sciences.

Subsequently, the research teams of the University of Trieste proposed projects aimed at verifying the application potential of the research trajectories identified by the companies, in order to foster an increase in the level of technological readiness (TRL) and accelerate their transfer to the market.

The winning projects

After a rigorous selection process, five projects were chosen for funding, confirming their strategic relevance and high innovation potential:

Development of innovative biomedical systems to restore the functions of the masticatory apparatus. Gianluca Turco collaborated with Advan srl to develop a project to characterise the mechanical resistance to fatigue and the maintenance of the connection between the components of dental implants.

Development of a Sustainable Predictive Model for Fishing Through the Integration of Artificial Intelligence Data. Luca Bortolussi, together with Doz Guido - Cooperativa Fra Pescatori of Monfalcone, proposed FishAI, a predictive artificial intelligence system for sustainable fishing in the Gulf of Trieste.

Digital Twin and BI for the Advanced Digitisation of Port Processes in the Port of Trieste. Giuseppe Borruso in partnership with Prodigys Technology srl, developed a Digital Twin and business intelligence project for the advanced digitisation of port processes in the Port of Trieste.

Analysis and feasibility study for the Intermodal Terminal of the Gorizia Freight Village. Giuseppe Borruso, in collaboration with Adriafer Rail Services srl, conducted a feasibility study for the Intermodal Terminal of the Gorizia Freight Village.

Application of Generative Artificial Intelligence for the Analysis of Treatment Protocols of Cardiovascular Diseases. Luca Bortolussi, with Beantech srl, developed ChatMED, an innovative chatbot based on generative artificial intelligence to support the treatment of cardiovascular diseases.

On this occasion, the Polo Tecnologico dell'Alto Adriatico presented the development actions of Lab Village, which will be located in the spaces of the Urban Center, to enable the meeting and collaboration between business and research. 

In the future of innovation and lab villages – which include some active experiments in Friuli Venezia Giulia and Veneto – it is expected that there will be an increasing number of market entry, brokerage and life-long learning services for researchers, entrepreneurs and human resources involved in shared technology transfer processes, where the public sector and business will operate in synergy.

Today the University of Trieste presented four degree courses on the Gorizia Campus during the UniTS ‘Open Day’ event, aimed at final-year high school students. It took place in the Main Hall of the campus on via Alviano 18.

Four courses, which will also be based in Gorizia in the academic year 2025-2026, have been confirmed: the five-year integrated Master’s Degree in Architecture and the bachelor’s degrees in International Relations and Diplomatic Studies, Health Care and Occupational and Environmental Health and Safety.

The initiative registered a significant increase in attendance compared to previous editions (up by15% compared to 2024). More than 400 young people took a day off from preparing for their high school exams to gather useful information on the courses offered by the University of Trieste in Gorizia and to understand how to manoeuvre everything required of their future university lives: from enrolment to fee reduction, from scholarships to accommodation.

The young participants, who over the course of the morning visited the laboratories and talked with lecturers from degree courses, for the most part came from the provinces of Friuli Venezia Giulia. More than sixty came from outside the region, particularly from Veneto, but there were also participants from Brescia, Mantua and Bergamo, and from as far as Ancona, Lecce and Syracuse.

At present, 632 students enrolled in the four degree courses gravitate around the UniTS Gorizia campus, a significant number which has grown in recent years with the establishment of the two healthcare degree courses. 20% of the students enrolled in the UniTS university hub in Gorizia come from outside the region.

Giuseppe Grimaldi, a research assistant in Cultural Anthropology at the Department of Humanities of the University of Trieste, has been awarded the 2024 prize of the Italian Society of Applied Anthropology (SIAA) for the best collaborative and applied research with the project O.S.A.RE. - Osservatorio Sfruttamento Agricolo e Resistenze (Observatory on Agricultural Exploitation and Resistance).

The objectives achieved by O.S.A.RE. contribute to combating the exploitation and illegal brokerage of workers, providing data on the spread of the phenomenon and best practices for systemic projects that support the fight against these social scourges. According to the SIAA judging committee, the project, which focused on sensitive areas in Campania, stood out for ‘its significant social impact and multi-level interaction, as well as the high degree of visibility and recognition of the anthropological contribution.’

The project presented by the UniTS research assistant demonstrates, according to the SIAA, ‘how the production of ethnographic knowledge can contribute to generating concrete impacts on public and institutional culture, fostering virtuous local policies that are more respectful of fundamental human rights.’

This motivation aligns with the core mission of the Italian Society of Applied Anthropology, active since 2013 with the aim of promoting the social use of anthropological knowledge and practices in the public sphere, the world of work, decision-making processes, and participatory democracy in Italy and abroad.

‘O.S.A.RE – explains Dr Giuseppe Grimaldi – was made possible thanks to the support and synergy between public institutions, such as the Campania Region and the University of Salerno, activist groups in Campania – particularly the Ex Canapificio social centre, which was the lead organisation of the project – and a diverse group of residents from the area where the intervention took place, who contributed decisively to its realisation.’

O.S.A.RE involved territories such as the Piana del Sele and the Volturno Castle area, which face challenges related to the fragility of their economic fabric, exacerbated by the presence of criminal organisations that cause poverty and social distress.

The project sought to shed light – through a combination of quantitative analysis and ethnography – on the systemic nature of exploitation in the agricultural sector. Throughout its implementation, it was grounded in co-research (a collaborative method where creating knowledge also builds organisation and autonomy), demonstrating how the experience of those subjected to exploitation is crucial for defining effective countermeasures, both in specific territories and in interactions with institutions.

Over the course of the project, more than 500 people were interviewed. Of these, based on the exploitation indicators outlined in the law against the illegal brokerage of workers, nearly 70% were found to be in conditions of ‘severe worker exploitation.’ The data was presented to institutional forums addressing the illegal brokerage of workers, and the methodology underlying O.S.A.RE was recognised as a best practice used in systemic initiatives to tackle worker exploitation.

‘O.S.A.RE – concludes Grimaldi – highlighted, in particular, how ineffective any approach to combating worker exploitation is if it does not address the legal, economic, and social systems upon which it is founded. A phenomenon that, albeit in different forms depending on the degree of vulnerability, affects all agricultural labourers, regardless of nationality.’