Domenica 12 maggio 20.000 volontari tornano nelle piazze di tutta Italia per distribuire l’Azalea della Ricerca AIRC durante la Festa della mamma, a fronte di una piccola donazione.

Fondazione AIRC per la Ricerca sul Cancro, è anche sponsor del 19° International p53 Workshop si terrà dal 13 al 16 Maggio al Trieste Convention Center. 

Il Workshop riunirà 300 partecipanti provenienti da 49 paesi, sotto la guida del Comitato Scientifico composto da Giannino Del Sal (Università degli Studi di Trieste, ICGEB-Trieste, IFOM-ETS Milano), Lawrence Banks (ICGEB, Trieste), Giovanni Blandino (Istituto Nazionale Tumori Regina Elena, Roma) e Gerry Melino (Università degli Studi di Roma “Tor Vergata”).

Il cancro continua a essere una delle sfide più complesse per la ricerca scientifica, per i sistemi sanitari e per l’intera società. Nel 2022 a livello mondiale i nuovi casi di cancro sono stati circa 20 milioni, e i decessi sono stati 9.7 milioni. Piu del 40% di tutti i casi di cancro presenta mutazioni nel gene TP53 nei tessuti malati. Il gene è infatti responsabile della produzione di uno dei più potenti soppressori tumorali. Sono quindi circa una decina di milioni i pazienti che si stima possono sviluppare, ogni anno, un tumore con mutazioni a carico di questo gene. La proteina p53 è dunque tra le molecole più studiate, anche perché è uno dei bersagli terapeutici più complessi da colpire.

Quando il gene TP53 funziona correttamente, la proteina p53 controlla a sua volta una vasta gamma di geni che regolano processi biologici cruciali per mantenere l’integrità del DNA e prevenire lo sviluppo del cancro. Per questo ruolo di protettore del materiale genetico, la proteina è stata soprannominata il “guardiano del genoma”. Tuttavia, quando subisce una mutazione, p53 nelle sue molteplici forme alterate aumenta la probabilità di una crescita incontrollata delle cellule, favorendo lo sviluppo di diversi tipi di tumore.

Il workshop esplorerà le ultime scoperte e innovazioni legate a TP53 e indagherà il suo intricato ruolo nel cancro e il suo potenziale impatto terapeutico.

Tra i 50 relatori previsti saranno presenti gli scienziati che hanno scoperto p53 nel lontano 1979 e coloro che hanno scoperto il ruolo di p53 nella sindrome di Li-Fraumeni (LFS), una malattia genetica ereditaria che predispone a un elevato rischio di sviluppare neoplasie durante tutto il corso della vita.

Beatrice Bartolomei, PhD in Nanotecnologie dell'Università di Trieste, ha vinto il premio per la miglior tesi di dottorato in Chimica Organica del 2024. 

Il riconoscimento è stato assegnato dalla Società Chimica Italiana (SCI) su indicazione del Consiglio Direttivo della Divisione di Chimica Organica.

Bartolomei, che ha conseguito il dottorato nel 36° ciclo sotto la supervisione del Prof. Maurizio Prato, lavorando nel Dipartimento di Scienze Chimiche e Farmaceutiche (DSCF), è autrice di una tesi incentrata sullo studio di una nuova generazione di nanoparticelle di carbonio luminescenti, i Carbon Nanodots. 

I Nanodots sono nanoparticelle sferiche, di dimensioni inferiori ai 10 nm, che vengono preparate trattando ad alta temperatura (200-300°C) piccole molecole organiche, come ad esempio aminoacidi. 

Bartolomei ha messo a punto nuove strategie sintetiche per la preparazione di Nanodots con proprietà interessanti per numerose applicazioni: ad esempio, sono stati preparati nuovi Nanodots chirali poi utilizzati come catalizzatori per promuovere trasformazioni organiche, sostituendo catalizzatori costosi e/o inquinanti. 

Durante il triennio di dottorato, Bartolomei ha svolto un periodo di ricerca presso l’Università del Michigan (USA), nel gruppo del Prof. Nicholas Kotov, dove ha avuto modo di approfondire alcuni aspetti riguardanti la struttura e le proprietà di queste particelle, utilizzando tecniche straordinariamente avanzate.

La dottoressa di ricerca di UniTS ritirerà il premio a Milano il prossimo 29 Agosto al 28° Congresso Nazionale della Società Chimica Italiana, durante il quale presenterà le parti più significative della sua tesi.

Fiftyfive years after the Apollo 11 landing, the Moon continues to reveal its dark side to scientists still studying Earth's natural satellite: for the first time, international research has identified more than 20 structures linked to now-buried craters and various inclined stratifications in the regolith, which is the layer of material composed of dust, rock and debris that lies on the Moon's surface and is the result of millennia of meteorite impacts and erosive processes. 

Coordinating the team of researchers is the Applied Geophysics group of Professor Michele Pipan from the Department of Mathematics, Computer Science and Geosciences at the University of Trieste.

Scientists interpreted geological structures at a depth of more than 30 metres from the lunar surface by analysing radar data collected by the Chinese Chang'E-4 mission from 2019, through the first rover landed on the moon's hidden face and integrating them with measurements from remote sensors.

The investigation involved part of the Van Kármán crater, located within the South Pole-Aitken Basin, an unexplored area of the satellite with a diameter of more than 180 km now at the centre of new geological revelations. For the first time, the researchers used deep learning algorithms based on artificial intelligence to collect and process the data, which allowed them to examine the radar data much more precisely and objectively than before, uncovering features and evolution of the hidden side of the lunar surface and revealing a complexity in the geometry of the regolith that was previously unknown. In fact, the regolith in the area observed does not have a constant thickness, contrary to previous assumptions, but varies between 5 and 15 metres.

‘These results demonstrate the importance of multidisciplinary analyses, which not only provide crucial information from a scientific point of view, but are also the essential starting point for the evaluation of potential lunar subsurface resources and for the planning of future missions and permanent lunar bases’, explains Michele Pipan, Professor of Applied Geophysics at the University of Trieste.

The research, published in the scientific journal Icarus, involved scientists from the University of Trieste, the INAF - National Institute of Astrophysics in Rome, Purdue University (USA), the Chinese Academy of Sciences and Zhejiang University (China). 

In January 2024, the same research team corrected and validated the radar data collected by the mission, available on the Lunar and Planetary data release system site of the National Astronomical Observatory of China and made them available to the international community through publication in the journal Scientific Data.

Currently, the University of Trieste research group that led this study is involved in a project selected by the European Space Agency (ESA) to send a magnetometer and radar system to the Moon for geophysical surveys of the lunar subsurface.

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Full study published in Icarus

Deep learning driven interpretation of Chang’E – 4 Lunar Penetrating Radar

G. Roncoroni a, E. Forte a, I. Santin a, A. ˇCernok a, A. Rajˇsi´c b, A. Frigeri c, W. Zhao d, G. Fang e,f,g, M. Pipan a

a Department of Mathematics, Informatics and Geosciences, University of Trieste, Italy
b Department of Earth, Atmospheric and Planetary Sciences, Purdue University, West Lafayette, IN, USA
c Istituto di Astrofisica e Planetologia Spaziali (IAPS), Istituto Nazionale di Astrofisica (INAF), Rome, Italy
d Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province, School of Earth Sciences, Zhejiang University, Hangzhou 310058, China
e Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China
f Key Laboratory of Electromagnetic Radiation and Sensing Technology, Chinese Academy of Sciences, Beijing 100190, China
g School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

The ELMA research project, jointly presented by UniTS and GSI Laboratories in Darmstadt, Germany, has been awarded a €150,000 grant to conduct a study on the energy response of monolithic active pixel sensors (MAPS).

ELMA is financed by funds from the Ministry of Foreign Affairs and International Cooperation (MAECI) within the framework of the Italy-Germany Cultural Cooperation, which aims to facilitate the access of Italian research personnel to large German research centres.

The research groups of the ELMA project, led by Giacomo Contin from the Physics Department of the University of Trieste and Silvia Masciocchi from the University of Heidelberg and the GSI laboratory, will systematically study the response of MAPS to particles accelerated to certain energies. The researchers will prepare and characterise functional MAPS samples, in planar and curved geometries, and irradiate them at the ion beams of the GSI-FAIR accelerator. The shape and size of the groups of pixels activated by the incident particles with different charge number and energy, and the analogue signal information stored by the detector logic, will be used to study the response and accurately calibrate the sensors for further use in various experimental applications.

The GSI laboratories will make local beam facilities available to the project and provide scientific and technical support.

The project will also provide the opportunity to establish a lasting collaboration between the Italian and German groups, enabling the exchange of students and scientific staff, routine access to each other's facilities, further joint research initiatives and scientific publications.

The funding also made it possible to announce research grants for undergraduate and graduate students and two post-doctoral positions as research assistant who will work on the proposed research and on the fabrication of the necessary setups for data collection. For information and to apply by 6th September 2024: https://amm.units.it/en/node/51946/assegno/pub and https://amm.units.it/en/node/51947/assegno/pub.

PHOTO: 2 x 2 pixel illustration of the ALPIDE chip, currently operating in the detector of the ALICE experiment at CERN.

Credits: courtesy of the ALICE Collaboration

The Mare Sopra outreach project devised by the University of Trieste to raise public awareness of rising sea levels caused by global warming is now in full swing. With almost 100 kilometres of coastline, Friuli Venezia Giulia is particularly vulnerable to risks caused by coastal erosion and flooding that could threaten local communities and infrastructure. Rising sea levels in the region could jeopardise not only the environment but also many of the activities that gravitate towards coastal areas, such as fishing and tourism.

In order to better understand the state of Friuli Venezia Giulia's coastline, researchers involved in the Mare Sopra project have recently begun monitoring the Trieste coastline with a special vehicle, a sort of kayak-pedalo-catamaran equipped with modern technology. In addition to the measurements that will be taken, these marine expeditions will be used to gather a vast collection of images and footage, making use of underwater cameras and drones. All updates and videos of upcoming activities will be made available on the Mare Sopra playlist on the University of Trieste's YouTube channel. 

At the end of the summer, the project will continue with further outreach activities on the beaches for schoolchildren and members of the public. The shooting of 360-degree spherical aerial videos captured by a drone is sure to be of particular interest. Images will be selected from underwater dives in order to create a high-resolution virtual tour.

At the end of all these activities, the main coastal locations will be marked with two lines. A yellow line will mark where the sea will be in 2050 and a red line its level in 2100.

Mare sopra is an interdisciplinary project conceived by Professor Stefano Furlani (UniTS), implemented with the collaboration of several partners and the contribution of the Autonomous Region of Friuli Venezia Giulia. It involves geomorphologists, sociologists and biologists from three university departments (Mathematics, Informatics and Geosciences; Political and Social Sciences; Life Sciences), as well as citizens, schools and associations.

Fast Radio Bursts (FRBs) are one of the most recent open mysteries in modern astrophysics: within milliseconds they release one of the highest amounts of energy observable in cosmic phenomena. Discovered just over a decade ago, these strong radio-band flashes come from mostly extragalactic sources, but their origin is still uncertain and many efforts are being made by the astrophysical community worldwide to try to understand the physical processes at their origin.

In very few cases, the rapid flash that characterises fast radio bursts coincides with a persistent radio emission. New research led by the National Institute of Astrophysics (INAF) has recorded the weakest persistent radio emission ever detected so far for an FRB. It is FRB20201124A, a fast radio burst discovered in 2020, whose source is located about 1.3 billion light years away. In addition to the work of INAF researchers, the study sees the collaboration of UniTS (Roberta Tripodi), the University of Bologna, the University of Calabria, and the international participation of research institutes and universities in China, the United States, Spain and Germany.

The observations, made possible by the world's most sensitive radio telescope, the Very Large Array (VLA) in the US, have verified the theoretical prediction that a plasma bubble is at the origin of the persistent radio emission of fast radio bursts. The results were published today in the journal Nature.

The new work also helps to circumscribe the nature of the driving force behind these mysterious flashes. According to the new data, either a magnetar (strongly magnetised neutron star) or an X-ray binary with a very high accretion regime, i.e. a binary system formed by a neutron star or a black hole that accretes material from a companion star at a very high rate, would be at the basis of the phenomenon. It is in fact the winds produced by the magnetar, or the binary X system, that 'inflate' the plasma bubble that gives rise to the persistent radio emission. There is therefore a direct physical relationship between the FRB 'engine' and the bubble, which is located in its immediate vicinity.

‘A nebular origin for the persistent radio emission of fast radio bursts’, by Gabriele Bruni, Luigi Piro, Yuan-Pei Yang, Salvatore Quai, Bing Zhang, Eliana Palazzi, Luciano Nicastro, Chiara Feruglio, Roberta Tripodi, Brendan O'Connor, Angela Gardini, Sandra Savaglio, Andrea Rossi, A. M. Nicuesa Guelbenzu, Rosita Paladino.

Happy Birthday UniTS also from the USA!

The D-ETEF laboratories’ research group from the Department of Engineering and Architecture have taken part in the sixth edition of the ‘International Conference on DC Microgrids’ organised by the IEEE (Institute of Electrical and Electronic Engineers, https://attend.ieee.org/icdcm-2024/) with a delegation consisting of Giorgio Sulligoi, Daniele Bosich and Andrea Alessia Tavagnutti, lecturers and researchers in electrical energy systems at our University.

The conference took place in Columbia (SC), at the University of South Carolina, a leading university for real-time studies and simulations on integrated, flexible and hybrid AC/DC electrical systems.

Prof. Sulligoi, who gave a keynote speech entitled ‘DC grids and ships: technological trends, proof of concepts, integrated ship design’, said: ‘The invitation to participate as a keynote speaker came from Professors Enrico Santi, general chair, and Roger Dougal, general co-chair, key figures in the field whom I had the good fortune to meet at several IEEE conferences during my PhD. Receiving an invitation from them to give a plenary session speech after twenty years of work in the field made me particularly honoured. It is an achievement which is the result of the work of the entire D-ETEF laboratories’ research team. Joining me in the proceedings were my colleagues Prof. Daniele Bosich, a specialist in the DC microgrids sector and track chair of the conference on Circuit Breakers and Protections, and Dr. Andrea Alessia Tavagnutti, who has just taken up her post at our university and was part of the PhD programme in Industrial and Information Engineering at MIT Boston, doing research in the specific field of DC microgrid storage. I would also like to thank our University for grasping the importance of having competitive laboratories to carry out power tests and trials on industrial-scale electrical systems, contributing to the renovation of spaces and achieving state-of-the-art infrastructures'.

The keynote speech took place on 8th August, so the UniTS team was able to publicly wish our University a happy 100th birthday!

Pictured: Prof. Giorgio Sulligoi and Enrico Santi, General Chairman of ICDCM 

Achieving the ‘dream reaction’, the long sought-after reaction that makes it possible to convert greenhouse gases into green fuels, is no longer just a dream, but a real scientific perspective encouraged by the results of a study that has brought together the main research bodies and universities in Friuli Venezia Giulia.

The Istituto Officina dei materiali of the National Research Council of Italy (CNR-IOM), the University of Udine, the University of Trieste, Elettra Sincrotrone and Area Science Park have implemented a synergy that has formed a broad and interdisciplinary research group: collaboration on the project has enabled the development of a technology for the preparation of innovative catalysts capable of promoting the transformation of methane, a potent greenhouse gas that negatively affects the energy balance of our planet by favouring global warming. 

The methodology identified concerned, in particular, the possibility of directly converting methane into methanol, a valuable ally in the energy transition process, by means of a new low-cost material based on Cerium and Copper, whose catalytic properties were explored thanks to state-of-the-art techniques available at the region's universities and research centres. 

‘The possibility of synthesising innovative materials at low cost has been investigated, avoiding the use of additional solvents and time-consuming steps in the preparation phase: this technology simply exploits the mechanical force that modifies the structure of the starting material and makes it more efficient in transforming methane into other molecules,’ explain Silvia Mauri, a researcher at CNR-Istituto Officina dei Materiali and Rudy Calligaro, a researcher at the University of Udine, both authors of the work. 

‘The result was twofold: on the one hand having identified a promising material for the catalysis process, and on the other hand having implemented our knowledge of the mechanisms underlying the effectiveness of these materials. This has been possible thanks to the use of advanced techniques using synchrotron light, together with the computing power available today. This will make it easier and faster from now on to further improve the design and use of these catalysts.'

The study therefore has important implications on supporting the process of the energy transition imposed by the consequences of global warming: ‘Methane is a precious resource and its exploitation represents a major challenge in heterogeneous catalysis: this is why the scientific community around the world is concentrating its efforts on the search for new materials that facilitate its transformation processes into products that can be used in a more sustainable way,’ adds Luca Braglia from Area Science Park. 'This fundamental study identifies a new class of catalysts prepared in an economically and environmentally more sustainable way. It also confirms how the simultaneous use of several advanced techniques and interdisciplinary skills is necessary to identify and develop new materials and technologies to support the ecological transition.’ 

Carlo Federico Pauletti, PhD student in Physics at the University of Trieste, was also part of the working group: ‘I contributed to the project by creating a computer model representing the catalyst synthesised by Piero Torelli's group (CNR-IOM), and then studying its behaviour through numerical simulations. What emerged from our study is, in agreement with the experimental results, a promising activity with regard to the direct conversion of methane into methanol, due to the particular nano-structural characteristics of the material, also observed in the experiments. 

The wide variety of techniques, both experimental and theoretical, used in the study of this system constitutes a considerable added value according to the UniTS doctoral student: ‘It has greatly improved our understanding of this reaction and the material used, and the great variety of approaches has made the work very stimulating, thanks to the continuous comparison with researchers from all the institutions involved,’ comments Pauletti.

The research, which demonstrates Italy's leading role in tackling the crucial challenge of the green transition and new materials, shows how cooperation between regional top scientific institutions brings results of great impact. The results of this collaboration have been described in the US scientific journal ‘Small’, published by Wiley, which also dedicated a cover page to the study.

The Interdepartmental Centre for Energy, Environment, and Transport “Giacomo Ciamician” of the University of Trieste has published, in collaboration with WWF Italy, the report entitled ‘The Steel Sector in Italy: Criticalities and Opportunities’: the innovative study explores the sustainability prospects of the Italian steel sector, highlighting current challenges and possible future scenarios.

The scientific contribution proposes a systemic view of the steel industrial sector, divided into several sections analysing global, European and Italian steel production, associated greenhouse gas emissions and decarbonisation opportunities related not only to environmental, but also to economic and social aspects. 

The work is primarily aimed at companies and institutions driving the transition to climate neutrality targets by 2050, considering the interests of organised civil society and trade unions. 

Innovative elements of the study include the quantitative and qualitative analysis of steel production, with a focus on the different production processes, including the electric arc furnace (EAF), the integrated steel mill (BF-BOF) and direct reduced iron (DRI) plants, short- and long-term decarbonisation strategies, with a focus on emerging technologies and renewable energies, and economic and employment assessments of transition scenarios towards more sustainable production.

The University of Trieste research team includes Andrea Mio from the Department of Engineering and Architecture (DIA), Romeo Danielis from the Department of Economics, Business, Mathematics and Statistics 'Bruno de Finetti' (DEAMS) and Giovanni Carrosio from the Department of Political and Social Sciences (DiSPeS). 

The UniTS team worked closely with WWF Italy to develop a detailed and multidisciplinary analysis of the sector. The project was supervised by Mariagrazia Midulla of WWF Italy, ensuring that the recommendations were aligned with environmental best practices.

'This report,' says Andrea Mio, who scientifically coordinated the study, 'represents an important step towards greater sustainability of the steel sector in Italy. The proposed strategies aim to reduce CO₂ emissions and promote the use of renewable energy, thus contributing to national and European climate goals.’

The study outlines three decarbonisation scenarios (Conservative, Prospective and Desirable), each with different environmental, economic and employment implications. The scenarios provide a comprehensive picture of possible developments, highlighting the benefits of a transition to low-carbon technologies.

The overall assessment of the decarbonisation scenarios presented by the researchers highlights some key considerations. From an environmental perspective, reducing CO2 emissions must be one of the main objectives. Among the different scenarios outlined, the desirable one envisages a significant decrease in emissions through the adoption of innovative technologies and the use of renewable energies.

From an economic perspective, the investments required for the transition to more sustainable production are considerable, but the long-term benefits, including energy cost savings and improvements in the competitiveness of the sector, are significant.

As far as employment effects are concerned, the transition to more sustainable steel production will lead to substantial changes, with likely growth in sectors related to renewable energy production and innovative plant maintenance.

Some technical details of the three scenarios

• Conservative Scenario: this is a business-as-usual scenario and envisages rather limited corrective actions, mainly related to the capture and reuse of CO₂ produced through existing technologies (BF-BOF and EAF). The overall reduction in emissions by 2050 will be -10.02 MtonCO₂ (-53.37% compared to 2022). Annual investments will be € 1.478 billion, with an estimated LCOP of € 612.76/tonne and an employment level of 42,600 in the steel sector and about 4,000 in the renewables sector.
• Prospective Scenario: DRI (Direct Reduced Iron) technology is introduced here using natural gas and biomethane with CO₂ capture. The reduction in emissions will be -12.735 MtonCO₂ (-67.85% compared to 2022). As in the previous case, CO2 capture is necessary for decarbonising this scenario. However, its implementation requires very stringent conditions to be conducted in a sustainable manner, conditions that are presented in the report. Annual investments will be € 1.845 billion, with an estimated LCOP of € 607.28/tonne and an employment level of 39,400 in the steel sector and about 5,000 in the renewables sector.
• Desirable Scenario: this scenario envisages the use of DRI technology based on green hydrogen and renewable sources coupled to the national energy mix. The overall emission reduction will be -12.735 MtonCO₂ (-67.84% compared to 2022), without introducing CO2 capture and with a potential further reduction linked to the progressive decarbonisation of the national energy sector. Annual investments will amount to € 1.386 billion, with an estimated LCOP of € 621.61/tonne and an employment level of 39,400 in the steel sector and more than 12,000 in the renewables sector.

In Memoriam

The authors also wished to honour the memory of Maurizio Fermeglia, full professor of Principles of Chemical Engineering and former Rector of the University of Trieste, who was passionate about environmental sustainability issues, a WWF collaborator and the association's delegate in Friuli Venezia Giulia. 

‘Maurizio contributed to the initial development of the work and helped us to combine scientific rigour with a climate and environmental vision in this report. He is greatly missed by all of us, and we want to honour him and remember him also on this occasion,’ reads the report's dedication.

Il report completo è disponibile sul sito del WWF Italia

To mark the 100th Anniversity of its founding, the University of Trieste is establishing the ‘PhD Innovation Awards’ to reward the best PhD theses submitted as part of the third-level courses held at UniTS.

For this purpose, 15,000 euros have been allocated, allowing for five prizes of three thousand euros each. 

The competition is aimed at PhD graduates who passed their final exams between 1st January 2023 and 30th June 2024. It will focus on a thesis that stood out for its innovation. Applications must be submitted online with University log in details by 13:00 on 29th August 2024.

The initiative aims to recognise the excellence and innovation of those who represent the future of research.

‘Investing in young researchers and promoting their cultural and professional growth is one of the most important objectives of our University.’ says prof. Alessandro Baraldi, Deputy Rector for scientific research and doctorates. ‘With the prizes we are awarding, we want to enhance ideas, originality and creativity, which are at the foundation of the knowledge and innovation we are celebrating with the 100th anniversary of UniTS.

If in recent years we have promoted access to the highest level of university education by increasing the number of PhD scholarships, now, through this initiative, we also wish to celebrate their achievements at the end of the process, which reflect the enormous commitment of our PhD students.'

The applications will be assessed in a first phase by a University panel who will select the ten best theses. The finalists will participate in a seminar of experts in the field of innovation who will then decide the final ranking and the awarding of the five prizes.

The award ceremony will take place at an event entitled ‘PhDs, authors of the future of knowledge’, planned for November 2024, at which the competition winners will present the results of their doctoral thesis research.

All information about the competition is available in the relevant Call for Applications.