From regenerating the heart to designing more efficient solar cells: FIS (Fondo Italiano per la Scienza) has allocated a further €3 million to two cutting-edge research projects at the University of Trieste. Funding has been awarded to SOFTEN, focused on new approaches to reversing fibrosis and promoting cardiac tissue regeneration, and to A DIGITal twin for efficient solar CELLs, set to develop a ‘digital twin’ capable of simulating a solar cell in all its complexity and of accelerating, in a predictive way, the discovery of new photovoltaic materials.

FIS is an initiative of the Italian Ministry of Universities and Research (MUR) which supports excellent research modelled on the European ERC programmes, with competitive schemes designed to accompany researchers through different stages of their careers. The two grants obtained confirm UniTS’s ability to produce cutting-edge research while also acting as an attractive hub for projects that are highly competitive at the international level.

The project SOFTEN – Reversal of cardiac fibrosis and promotion of tissue regeneration through controlled SOFTENing of the extracellular matrix milieu, coordinated by Pasquale Sacco of the Department of Life Sciences, has been awarded around €1.65 million and addresses one of the most complex challenges in contemporary medicine: after an injury, the adult human heart is unable to regenerate effectively and tends to develop fibrosis, compromising its function.

The idea stems from observations in species such as the zebrafish, which can regenerate the heart thanks to a temporary ‘softening’ of the extracellular matrix. SOFTEN aims to reproduce and control this behaviour using specifically designed biomaterials, combining polymer chemistry, materials design and cellular and molecular biology methods to understand and steer the mechanisms of cardiac tissue repair.

The project A DIGITal twin for efficient solar CELLs, funded with around €1.33 million, is led by Virginia Carnevali, who will move from the École Polytechnique Fédérale de Lausanne (EPFL) to the Department of Physics at the University of Trieste to carry out the study.

The research aims to develop a digital twin of a solar cell capable of simulating the device in its full physical and structural complexity and of providing predictive insight both into conversion efficiency and into the discovery of new photovoltaic materials. The approach combines quantum simulations, molecular dynamics, statistical methods and experimental data, with the goal of bringing fundamental research and device engineering closer together in a key field for renewable energy.

As the researcher explains, Trieste and the Department of Physics were chosen for their internationally recognised expertise in developing codes and simulation techniques to study the structural and electronic properties of materials. The city also offers outstanding experimental facilities and a consolidated network of scientific partnerships built up since her PhD, which she completed in Trieste.

The FIS grants awarded to the projects led by Sacco and Carnevali add to the three already announced on 1st December 2025, attributed to Paolo Fornasiero (€2.3 million) and Federico Rosei (€1.9 million) of the Department of Chemical and Pharmaceutical Sciences, and to Matteo Marinelli (€1.1 million) of the Department of Physics. Five UniTS projects have been awarded funding by FIS in this round, amounting to €8.2 million overall.

‘We are very satisfied with these results,’ commented Rector Donata Vianelli. ‘FIS applies particularly rigorous criteria in evaluating projects, and the outcome confirms the University of Trieste’s ability to develop research that attracts funding and, in this case, human capital as well. The selected programmes reflect our commitment to key research areas: from biomedical research and biomaterials to tackle major health challenges, to advanced modelling of materials and devices for renewable energy.’