Dr Antonella Muzzo, research fellow at the University of Trieste, has received the ASCPT Presidential Trainee Award, a prestigious recognition granted by the American Society for Clinical Pharmacology and Therapeutics (ASCPT) to early-career researchers who have distinguished themselves for scientific excellence.

Each year, the Scientific Program Committee selects the highest-scoring abstracts submitted by clinical pharmacologists and translational researchers in training, granting them special recognition as part of the Society’s Annual Meeting.

The award was granted for the doctoral research project carried out at the Department of Medical, Surgical and Health Sciences of the University of Trieste and at IRCCS Burlo Garofolo, under the supervision of Professors Marianna Lucafò, Giuliana Decorti and Gabriele Stocco.

The work was presented as a poster entitled “Thiopurine treatment responses in pediatric inflammatory bowel disease are determined by a newly identified TRIM32-cGAS-STING pathway: a pharmacokinetic study in organoids”.

The project also involved the Department of Life Sciences, with which Professors Lucafò and Meroni and Dr Lazzari are affiliated.

The study provides an integrated analysis of the molecular and pharmacokinetic mechanisms that regulate the response to thiopurines in paediatric patients with inflammatory bowel disease (IBD), using an innovative, patient-specific preclinical model: intestinal organoids derived from patients affected by IBD.

For the first time, the research demonstrates that thiopurines exert direct pharmacological effects on intestinal epithelial cells, in addition to their well-known systemic immunosuppressive actions. The findings also highlight significant interindividual variability in treatment response, mainly determined by pharmacokinetic factors.

At the intestinal cell level, thiopurines show an anti-inflammatory effect by acting on specific molecular mechanisms involved in inflammation, including the TRIM32-cGAS-STING and NF-κB/p65 pathways.

Overall, these findings contribute to the development of personalised therapeutic strategies and to the identification of new potential therapeutic approaches in the paediatric field.