Results were presented in Trieste from the cross-border clinical research project X-BRAIN.net - Network for cross-border cooperation aimed at the rehabilitation of stroke patients with innovative technologies, funded by the Interreg Italy-Slovenia Programme with a total budget of €750,000.

Coordinated by the Department of Medicine, Surgery and Health Sciences at the University of Trieste, the project involved the participation of the Science and Research Centre Koper (ZRS Koper), the Neurological Clinic of ASUGI’s Cattinara Hospital and the Neurology Unit of Izola General Hospital.

The aim of the project is to make stroke rehabilitation more effective, a crucial challenge for today's healthcare system, by activating a targeted protocol in the very first days, enhanced by the use of innovative technologies. ‘The multimodal approach,’ explains project coordinator Professor Gianni Biolo of the University of Trieste, ‘combines nutritional integration, cognitive training through virtual reality and prehabilitation activities to ensure the maintenance of muscle mass and strength and to modulate the reorganisation processes within the central nervous system that are typical of immobility, promoting a more rapid recovery at the end of the period of inactivity.’

The experimental phase was conducted on healthy volunteers, with an average age of 68, who had to stay in bed for ten days. ‘From a nutritional point of view,’ continues Biolo, ‘we intervened by increasing protein intake from 0.8 to 1.4 grams per kilogram of body weight per day and introducing a daily intake of 3.5 grams of the amino acid leucine, in order to ensure the maintenance of muscle mass.’

‘Through immersive and multisensory environments,’ explains Dr Luka Šlosar of the Science and Research Centre Koper, ‘the volunteers underwent mental training that preserved the flow of neuromuscular information and modulated the reorganisation processes within the central nervous system. In this way, it was possible to promote the maintenance of muscle strength and accelerate recovery times.’

‘Strokes are one of the leading causes of disability worldwide,’ emphasises Professor Paolo Manganotti, director of the Neurological Clinic at Cattinara Hospital, ‘with consequences that profoundly affect daily life. Intervening in the first few days with targeted rehabilitation programmes is essential for recovering compromised functions and improving quality of life. Thanks to the project, we were able to set up an active room entirely dedicated to the acute phase, equipped with virtual reality devices that allow for safe, stimulating and personalised exercises. The immersive and interactive aspect increases patient motivation and consistency, which are decisive factors in a successful recovery.’