World Cancer Day is observed on 4th February, promoted by the Union for International Cancer Control (UICC) to raise awareness of the importance of prevention, early diagnosis, and scientific research in the fight against cancer. It is an opportunity to reaffirm the scientific community’s dedication to tackling a disease that remains one of the greatest global health challenges.

This year, we want to highlight that cancer research is not limited to the medical and clinical fields but involves a vast network of multidisciplinary expertise. Biologists, chemists, engineers, and computer scientists also contribute their knowledge to develop new prevention, diagnostic, and treatment strategies.

From studying the biological mechanisms behind tumour transformation to developing new drugs and biomarkers, and applying computational models to analyse genetic data and identify targeted therapies—science is exploring multiple avenues to combat cancer.

On this occasion, we share the diverse and complementary approaches in oncology research through the voices of UniTS researchers.

Giannino DEL SAL – Applied Biology, Department of Life Sciences

‘We study how cancerous cells communicate with the surrounding tissue, both in the early stages of the disease and during metastasis. We analyse how the signals exchanged in this communication promote tumour growth and enable cancer cells to resist therapies, helping us identify weak points to target.

In this project, we aim to gain a deeper understanding of the early phases, when a competition arises between transforming cells and healthy ones in an otherwise normal tissue. Understanding these dynamics will help us develop strategies to intervene earlier and more effectively against cancer.

Our goal is to provide tools to halt cancer in its earliest stages, or even prevent it entirely, as well as to improve treatment strategies for advanced disease and therapy-resistant cases.’

Sabrina PRICL – Chemical Engineering, Department of Engineering and Architecture

‘From high-performance computational design to in vivo experimentation, we collaborate with several international research teams to develop nanomedicines and nanocarriers for cancer diagnosis, therapy, and imaging.

Thanks to funding from AIRC, the Friuli Venezia Giulia Region, the European Commission, and the National Recovery and Resilience Plan (NRRP), we integrate in silico techniques with experimental validation to study oncogenes: altered genes that can drive uncontrolled cell growth and contribute to cancer development. This approach opens new avenues for the creation of more effective and targeted treatments.

Our next challenges? Enhancing treatment selectivity, reducing side effects, and translating our discoveries into widely accessible clinical solutions.’

Giulio CARAVAGNA – Computer Science, and Alice ANTONELLO – PhD in Applied Data Science and Artificial Intelligence, Department of Mathematics, Computer Science, and Geosciences

‘In collaboration with the Aviano Cancer Research and Treatment Centre and San Raffaele Hospital in Milan, we have developed computational models to study the behaviour of certain leukaemias. The results we are finalising are highly promising, helping us clarify molecular mechanisms that drive disease progression over time.

This project, funded by an AIRC grant for researchers under 40, has also sparked new research questions: Can these tools be applied to other cancers? Can we use a systematic approach to characterise disease evolution over time and uncover vulnerabilities?’ (G. Caravagna)

‘In November 2024, I was awarded a three-year AIRC Italy Post-Doc Fellowship for PhD researchers. My project applies artificial intelligence methods to genomic data from DNA to study the relationship between specific mutations and exposure to mutagens—substances or factors that can cause DNA alterations.

This is a crucial first step in identifying risk factors linked to certain diseases and developing strategies to counteract their effects.’ (A. Antonello)